A Strategy for Reproducible Protein Quantitation in Gene Therapies Using Ion Mobility Spectrometry
Accurate protein expression quantification is critical to advance and accelerate gene therapy development. However, measuring protein expression reproducibly is a challenge for many traditional assays due to limitations in sensitivity and selectivity.
For today’s gene therapy developer, Ion Mobility Spectrometry (IMS) delivers the sensitivity and selectivity needed to accurately identify and quantify protein products across complex biological matrices. Compared to traditional technologies, IMS reliably distinguishes target protein products from similar endogenous compounds and detects therapeutic proteins expressed at low levels. It is also adept at navigating blood and tissue samples, where such complex environments can add variability to chromatographic readouts.
In this webinar:
Our expert panelists will discuss strategies to overcome challenges in protein quantitation using Ion Mobility Spectrometry, from early R&D through preclinical and clinical trials for gene therapies.
Key learnings from the webinar will include how the technology can:
- Resolve isomer differentiation and low-abundance protein challenges
- Increase confidence in target protein expression quantification results
- Provide an accelerated and scalable strategy for gene therapy development
Fill out the form to access exclusive insights to enhance your bioanalysis today!